Article
Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.
The Biochemical journal - 15 May 1992
Lamb H K, van den Hombergh J P, Newton G H, Moore J D, Roberts C F, Hawkins A R
Abstract excerpt
The qutC gene encoding dehydroshikimate dehydratase has been constitutively overexpressed in Aspergillus nidulans from a range of 1-30-fold over the normal wild-type level. This overexpression leads to impaired growth in minimal medium which can be alleviated by the addition of aromatic amino acids to the medium. Overexpression of the qutC gene in mutant strains lacking protocatechuic acid (PCA) oxygenase leads...
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