Article
High-level quinolone resistance in clinical isolates of Campylobacter jejuni.
The Journal of infectious diseases - 1 Apr 1992
Segreti J, Gootz T D, Goodman L J, Parkhurst G W, Quinn J P, Martin B A, Trenholme G M
Abstract excerpt
During a recent clinical trial of ciprofloxacin in the therapy of acute diarrhea, two subjects infected with Campylobacter jejuni who received ciprofloxacin failed microbiologically and one also failed clinically. Although both pretreatment isolates were susceptible to ciprofloxacin, the posttreatment isolates were resistant to ciprofloxacin (MIC = 32 micrograms/ml) and to other quinolones. The posttreatment...
Topics
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- Campylobacter Infections
- Campylobacter jejuni
- Ciprofloxacin
- Drug Resistance, Microbial
- Humans
- Mutation
- Serial Passage
- Topoisomerase II Inhibitors