Article
Molecular variants of human papillomavirus type 16 from four continents suggest ancient pandemic spread of the virus and its coevolution with humankind.
Journal of virology - 1 Apr 1992
Chan S Y, Ho L, Ong C K, Chow V, Drescher B, Dürst M, ter Meulen J, Villa L, Luande J, Mgaya H N
Abstract excerpt
We have amplified by the polymerase chain reaction, cloned, and sequenced genomic segments of 118 human papillomavirus type 16 (HPV-16) isolates from 76 cervical biopsy, 14 cervical smear, 3 vulval biopsy, 2 penile biopsy, 2 anal biopsy, and 1 vaginal biopsy sample and two cell lines. The specimens were taken from patients in four countries--Singapore, Brazil, Tanzania, and Germany. The sequence of a 364-bp...
Topics
- Base Sequence
- Biological Evolution
- DNA, Viral
- Genetic Variation
- Humans
- Molecular Sequence Data
- Open Reading Frames
- Papilloma
- Papillomaviridae
- Phylogeny
- Polymerase Chain Reaction