Article
Evaluation of the actions and interactions of retinoic acid and epidermal growth factor on transformed urothelial cells in culture: implications for the use of retinoid therapy in the treatment of bladder cancer patients.
Clinical oncology (Royal College of Radiologists (Great Britain)) - 1 Jan 1992
Nutting C, Chowaniec J
Abstract excerpt
The effects and interactions were investigated of the two growth regulatory molecules alltrans retinoic acid (RA), and epidermal growth factor (EGF) on the in vitro expression by bladder cancer cell lines of the transformed phenotype (anchorage-independent growth in soft agar). When tested individually, the two molecules had opposite effects: RA (10(-11) to 10(-5) M) caused a dose-related reduction in...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Dose-Response Relationship, Drug
- Down-Regulation
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Phenotype
- Rats