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Article

Karyotypic and phenotypic changes during in vitro aging of human endothelial cells.

Journal of cellular physiology - 1 Jan 1992

Johnson T E, Umbenhauer D R, Hill R, Bradt C, Mueller S N, Levine E M, Nichols W W

Abstract excerpt

Karyotypic and phenotypic changes were found in human adult endothelial cells (EC) during aging in vitro. A trisomy of chromosome 11 was found in 11 out of 12 EC cultures examined, derived from 9 cell lines from 8 donors. The incidence of this trisomy in some cell lines increased over time from 0% to as much as 100% near the end of their in vitro life span. A number of oncogenes and other important genes are on...

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PMID: 1309825
DOI: 10.1002/jcp.1041500104

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ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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