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Article

Karyotypic and phenotypic changes during in vitro aging of human endothelial cells.

Journal of cellular physiology - 1 Jan 1992

Johnson T E, Umbenhauer D R, Hill R, Bradt C, Mueller S N, Levine E M, Nichols W W

Abstract excerpt

Karyotypic and phenotypic changes were found in human adult endothelial cells (EC) during aging in vitro. A trisomy of chromosome 11 was found in 11 out of 12 EC cultures examined, derived from 9 cell lines from 8 donors. The incidence of this trisomy in some cell lines increased over time from 0...

Topics

Adult
Aged
Aged, 80 and over
Cells, Cultured
Cellular Senescence
Endothelium, Vascular
Female
Humans
Karyotyping
Longitudinal Studies
Male
Middle Aged
Muscle, Smooth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptidyl-Dipeptidase A

Phenotype

von Willebrand Factor

Source

Identifiers

PMID: 1309825
DOI: 10.1002/jcp.1041500104

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1309825-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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