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Placental Iodothyronine Deiodinase Expression in Normal and Growth-Restricted Human Pregnancies

1 Sept 2003

Abstract excerpt

We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities...

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PMID: 12970328
DOI: 10.1210/jc.2003-030228

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