Article
Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion.
International journal of molecular medicine - 1 Oct 2003
Emanuele Enzo, Falcone Colomba, Carabela Maria, Minoretti Piercarlo, D'Angelo Angela, Montagna Lorenza, Geroldi Diego
Abstract excerpt
The disturbances in coronary vasomotor tone have been extensively analyzed, but the exact molecular mechanisms underlying abnormal coronary vasomotion remain to be elucidated. It has been suggested that impaired coronary vasoreactivity can be the expression of a defect in vascular smooth muscle cells. A mouse model of human variant (vasospastic) angina has been recently obtained by disruption of Kir6.1/Kcnj8, a...
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