Article
The host immune response may be responsible for selection of envelope and precore/core variants of HBV.
Progress in liver diseases - 1 Jan 1992
Thomas H C, Carman W F
Abstract excerpt
The appearance of replication-competent variants of HBV with mutations in the envelope and precore/core proteins emphasizes that these proteins are the focus of immune selection pressure in the human host. The sequence and speed of application of the multiple selection pressures (humoral and possibly cellular) will determine the virological and clinical outcome. When these variant viruses are passed to a new...
Topics
- Genetic Variation
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B Core Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Virus Replication