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Article

Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line.

European journal of biochemistry - 1 Sept 2003

Qi Hui-Ling, Zhang Ying, Ma Jun, Guo Peng, Zhang Xia-Ying, Chen Hui-Li

Abstract excerpt

The effect of insulin on cancer metastatic potential was studied in a human hepatocarcinoma cell line, H7721. Cell adhesion to human umbilical vein endothelial cells (HUVECs) and laminin as well as chemotactic cell migration and invasion were selected as the indices of metastasis-related phenotypes for assessment of metastatic potential ex vivo. The results indicated that insulin enhanced all of these...

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PMID: 12950263
DOI: 10.1046/j.1432-1033.2003.03767.x

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