Article
[The study of orthopoxvirus genes for Kelch-like proteins. II. Construction of cowpox virus variants with targeted gene deletions].
Molekuliarnaia biologiia - 1 Jan 2000
Kolosova I V, Seregin S V, Kochneva G V, Riabchikova E I, Bessmel'tseva E V, Babkina I N, Solenova T E, Babkin I V, Shchelkunov S N
Abstract excerpt
Integrative plasmids p delta C, p delta D, and p delta G were designed to contain a selective marker beyond the region of homology to virus DNA and to allow construction of recombinant cowpox viruses (CPV) that lack C18L, D11L, or G3L coding for kelch-like proteins. CPV mutants lacking one (C18L, D11L, or G3L), two (D11L/G3L or C18L/D11L), or three (D11L/G3L/C18L, that is, all) kelch-like protein genes of the...
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