Article
Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes.
Diabetes - 1 Sept 2003
Westerholm-Ormio Mia, Vaarala Outi, Pihkala Päivi, Ilonen Jorma, Savilahti Erkki
Abstract excerpt
Involvement of gut immune system has been implicated in the pathogenesis of type 1 diabetes. However, few studies have been performed on the gut mucosa from patients with type 1 diabetes. Thus, we characterized the stage of immune activation in jejunal biopsy samples from 31 children with type 1 diabetes by immunohistochemistry, in situ hybridization, and RT-PCR. We found enhanced expressions of HLA-DR, HLA-DP,...
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