Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome.

doi:10.1093/sleep/26.5.592

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Article

Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome.

Sleep - 1 Aug 2003

Lavie Lena, Lotan Rachel, Hochberg Irit, Herer Paula, Lavie Peretz, Levy Andrew P

Abstract excerpt

STUDY OBJECTIVES: Obstructive sleep apnea syndrome is associated with a marked increase in the risk for cardiovascular disease. Increased oxidative stress and leukocyte adhesiveness have been implicated as fundamental pathophysiologic mechanisms underlying the increased susceptibility in these patients. Haptoglobin is an antioxidant and immunomodulatory protein encoded by 2 alleles with profoundly different...

Topics

Alleles
Body Mass Index
Cardiovascular Diseases
Female
Genetic Predisposition to Disease
Haptoglobins
Humans
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Risk Factors
Severity of Illness Index
Sleep Apnea, Obstructive

Source

Open in PubMed

Identifiers

PMID: 12938813
DOI: 10.1093/sleep/26.5.592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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