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Article

Two-component systems of Helicobacter pylori contribute to virulence in a mouse infection model.

Infection and immunity - 1 Sept 2003

Panthel Klaus, Dietz Patricia, Haas Rainer, Beier Dagmar

Abstract excerpt

Helicobacter pylori encodes three histidine kinases and five response regulators belonging to the family of two-component regulatory systems which are involved in transcriptional control. Here we demonstrate that isogenic mutants of H. pylori P76 with deletions of the response regulator open reading frame (ORF) HP1365 and ORFs HP244, HP165, and HP1364 encoding histidine kinases are unable to colonize the stomachs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12933888
DOI: 10.1128/IAI.71.9.5381-5385.2003
PMCID: PMC187308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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