Article
Mutations to essential orphan response regulator HP1043 of Helicobacter pylori result in growth-stage regulatory defects.
Infection and immunity - 1 May 2013
Olekhnovich Igor N, Vitko Serhiy, Chertihin Olga, Hontecillas Raquel, Viladomiu Monica, Bassaganya-Riera Josep, Hoffman Paul S
Abstract excerpt
Helicobacter pylori establishes lifelong infections of the gastric mucosa, a niche considered hostile to most microbes. While responses to gastric acidity and local inflammation are understood, little is known as to how they are integrated into homeostatic control of cell division and growth-stage gene expression. Here we investigate the essential orphan response regulator HP1043, a member of the OmpR/PhoB...
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