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Article

An enhanced U6 promoter for synthesis of short hairpin RNA.

Nucleic acids research - 1 Sept 2003

Xia Xu Gang, Zhou Hongxia, Ding Hongliu, Affar El Bashir, Shi Yang, Xu Zuoshang

Abstract excerpt

Short hairpin RNAs (shRNAs) transcribed by RNA polymerase III (Pol III) promoters can trigger sequence-selective gene silencing in culture and in vivo and, therefore, may be developed to treat diseases caused by dominant, gain-of-function type of gene mutations. These diseases develop in people b...

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Identifiers

PMID: 12930974
DOI: 10.1093/nar/gng098
PMCID: PMC212820

Genes

SOD1

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12930974-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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