Article
A new animal model for human undifferentiated thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association - 1 Jun 2003
Viaggi M, Dagrosa M A, Belli C, Larripa I, Gangitano D, Cabrini R, Pisarev M A, Juvenal G
Abstract excerpt
An animal model of undifferentiated thyroid carcinoma (UTC), which may be useful for studying tumorigenesis and response to new therapies, is described. The UTC human cell line ARO was implanted into the back of the nude mice. The histology, induction of metastasis, and biokinetics of in vivo and in vitro growth, as well as cytogenetic and molecular aspects were studied. The tumor showed extensive viability with...
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