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Article

Development and characterization of an infectious cDNA clone of the modified live virus vaccine strain of equine arteritis virus.

Clinical and vaccine immunology : CVI - 1 Aug 2012

Zhang Jianqiang, Go Yun Young, Huang Chengjin M, Meade Barry J, Lu Zhengchun, Snijder Eric J, Timoney Peter J, Balasuriya Udeni B R

Abstract excerpt

A stable full-length cDNA clone of the modified live virus (MLV) vaccine strain of equine arteritis virus (EAV) was developed. RNA transcripts generated from this plasmid (pEAVrMLV) were infectious upon transfection into mammalian cells, and the resultant recombinant virus (rMLV) had 100% nucleotide identity to the parental MLV vaccine strain of EAV. A single silent nucleotide substitution was introduced into the...

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Identifiers

PMID: 22739697
DOI: 10.1128/CVI.00302-12
PMCID: PMC3416077

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