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Article

A novel method of generating neuronal cell lines from gene-knockout mice to study prion protein membrane orientation.

The European journal of neuroscience - 1 Aug 2003

Holme Andrea, Daniels Maki, Sassoon Judyth, Brown David R

Abstract excerpt

The technology of gene knockout and transgenic mice has allowed the study of the role of genes and their proteins in animal physiology and metabolism. However, these techniques have often been found to be limited in that some genetic manipulations of mice led either to a fatal phenotype or to com...

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Identifiers

PMID: 12911753
DOI: 10.1046/j.1460-9568.2003.02780.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12911753-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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