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Article

The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans.

Molecular genetics and genomics : MGG - 1 Nov 2003

Kuervers L M, Jones C L, O'Neil N J, Baillie D L

Abstract excerpt

The let-767 gene encodes a protein that is similar to mammalian steroid enzymes that are responsible for the reduction of 17-beta hydroxysteroid hormones. Caenorhabditis elegans is incapable of the de novo synthesis of cholesterol. Therefore, this free-living nematode must extract cholesterol from its environment and modify it to form steroid hormones that are necessary for its survival. C. elegans is unable to...

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PMID: 12905072
DOI: 10.1007/s00438-003-0900-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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