Article
Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians.
Human genetics - 1 Sept 2003
Thameem Farook, Yang Xiaolin, Permana Paska A, Wolford Johanna K, Bogardus Clifton, Prochazka Michal
Abstract excerpt
Elevation of plasma glucose concentration may induce generation of oxygen-free radicals, which can play an important role in the progression of diabetes and/or development of its complications. Various glutathione transferases utilize the availability of reduced glutathione for the cellular defense against oxygen-free radicals. One such enzyme is microsomal glutathione S-transferase 3 encoded by MGST3, which maps...
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