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Article

MELAS: clinical phenotype and morphological brain abnormalities.

Acta neuropathologica - 1 Sept 2003

Sparaco M, Simonati A, Cavallaro T, Bartolomei L, Grauso M, Piscioli F, Morelli L, Rizzuto N

Abstract excerpt

We describe the clinical and neuropathological findings of three unrelated autopsy cases of MELAS harboring the A3243G transition in the mitochondrial DNA (mtDNA). Using immunohistochemical techniques, we studied the expression of several subunits of the respiratory chain in various brain regions from the same cases. In all three cases there was a reduced immunocytochemical staining for mtDNA-encoded subunits of...

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Identifiers

PMID: 12910360
DOI: 10.1007/s00401-003-0716-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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