Article
A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma.
Gastroenterology - 1 Aug 2003
Machado José Carlos, Figueiredo Céu, Canedo Paulo, Pharoah Paul, Carvalho Ralph, Nabais Sérgio, Castro Alves Catarina, Campos Maria Luisa, Van Doorn Leen-Jan, Caldas Carlos, Seruca Raquel, Carneiro Fátima, Sobrinho-Simões Manuel
Abstract excerpt
BACKGROUND & AIMS: Pro-inflammatory polymorphisms within the genes interleukin (IL)-1B and IL-1RN are associated with risk for gastric carcinoma (GC) in Helicobacter pylori-infected individuals. We aimed to determine the association between variation of the tumor necrosis factor (TNF)-alpha gene and the risk for chronic atrophic gastritis (CAG) and GC. We also investigated the extent to which the combined effect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.