Transthyretin Val122Ile, accumulated Abeta, and inclusion-body myositis aspects in cultured muscle.

Abstract excerpt

Cultured muscle fibers (CMF) from a patient with inclusion-body myositis (IBM) and cardiac amyloidosis associated with the transthyretin (TTR) Val122Ile mutation contained aspects of the IBM phenotype: vacuolation, congophilic inclusions, and clusters of immunocolocalizing amyloid beta-peptide (Abeta) and TTR accumulations. These abnormalities are never present in normal human CMF. These perturbations were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid
• Share to Amyloid beta-Protein Precursor
• Share to Coloring Agents