Article
Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study.
Circulation - 5 Aug 2003
Wang Thomas J, Nam Byung-Ho, D'Agostino Ralph B, Wolf Philip A, Lloyd-Jones Donald M, MacRae Calum A, Wilson Peter W, Polak Joseph F, O'Donnell Christopher J
Abstract excerpt
BACKGROUND: A family history of coronary heart disease (CHD) is an independent risk factor for cardiovascular events. However, the mechanisms underlying this susceptibility have not been fully elucidated. We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, which is detectable by noninvasive imaging. METHODS AND RESULTS: We studied 1662 subjects (mean...
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