Article
X-ray-induced mutations in Escherichia coli K-12 strains with altered DNA polymerase I activities.
Mutation research - 25 Jul 2003
Nagata Yuki, Kawata Masakado, Komura Jun-ichiro, Ono Tetsuya, Yamamoto Kazuo
Abstract excerpt
Spectra of ionizing radiation mutagenesis were determined by sequencing X-ray-induced endogenous tonB gene mutations in Escherichia coli polA strains. We used two polA alleles, the polA1 mutation, defective for Klenow domain, and the polA107 mutation, defective for flap domain. We demonstrated that irradiation of 75 and 50 Gy X-rays could induce 3.8- and 2.6-fold more of tonB mutation in polA1 and polA107...
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