Article
Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease.
The Journal of infectious diseases - 1 Aug 2003
Ma Xin, Reich Robert A, Wright John A, Tooker Heather R, Teeter Larry D, Musser James M, Graviss Edward A
Abstract excerpt
Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to be homozygous for the IL-8 -251A allele, compared with control subjects (odds ratio [OR], 3.41; 95% confidence...
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