Article
Estimating effective population size from samples of sequences: a bootstrap Monte Carlo integration method.
Genetical research - 1 Dec 1992
Felsenstein J
Abstract excerpt
We would like to use maximum likelihood to estimate parameters such as the effective population size N(e) or, if we do not know mutation rates, the product 4N(e) mu of mutation rate per site and effective population size. To compute the likelihood for a sample of unrecombined nucleotide sequences taken from a random-mating population it is necessary to sum over all genealogies that could have led to the...
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