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Article

Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.

Molecular and cellular biology - 1 Aug 2003

Forgues Marshonna, Difilippantonio Michael J, Linke Steven P, Ried Thomas, Nagashima Kunio, Feden Jeffrey, Valerie Kristoffer, Fukasawa Kenji, Wang Xin W

Abstract excerpt

Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer cells, we examined the effect of HBx on centrosomes. We found that HBx induced supernumerary centrosomes and multipolar spindles. This effect was independent of mutations in the p21 gene. Furthermore, the ability of...

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Identifiers

PMID: 12861014
DOI: 10.1128/MCB.23.15.5282-5292.2003
PMCID: PMC165739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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