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Article

Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8.

Molecular and cellular biology - 1 Aug 2003

Atlashkin Vadim, Kreykenbohm Vera, Eskelinen Eeva-Liisa, Wenzel Dirk, Fayyazi Afshin, Fischer von Mollard Gabriele

Abstract excerpt

SNARE proteins participate in recognition and fusion of membranes. A SNARE complex consisting of vti1b, syntaxin 8, syntaxin 7, and endobrevin/VAMP-8 which is required for fusion of late endosomes in vitro has been identified recently. Here, we generated mice deficient in vti1b to study the function of this protein in vivo. vti1b-deficient mice had reduced amounts of syntaxin 8 due to degradation of the syntaxin...

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Identifiers

PMID: 12861006
DOI: 10.1128/MCB.23.15.5198-5207.2003
PMCID: PMC165714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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