Article
Endothelial differentiation of hematopoietic stem and progenitor cells from patients with multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2008
Ria Roberto, Piccoli Claudia, Cirulli Teresa, Falzetti Franca, Mangialardi Giuseppe, Guidolin Diego, Tabilio Antonio, Di Renzo Nicola, Guarini Attilio, Ribatti Domenico, Dammacco Franco, Vacca Angelo
Abstract excerpt
PURPOSE: Vasculogenesis is a physiologic process typical of fetal development in which new blood vessels develop from undifferentiated precursors (or angioblasts). In tumors, near angiogenesis, vasculogenesis contributes to the formation of the microvascular plexus that is important for diffusion. Here, we show that hematopoietic stem and progenitor cells (HSPC) of multiple myeloma (MM) patients are able to...
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