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Article

Is there a link between environmental factors and a genetic predisposition to cancer? A lesson from a familial cluster of gastric cancers.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2003

Rocco A, Staibano S, Ottini L, Mezza E, Somma P, Mariani-Costantini R, Budillon G, Nardone G

Abstract excerpt

To determine the prevalence of gastric precancerous lesions and mucosal genetic alterations in relatives of a cluster of familial gastric cancer (FGC), we studied a kindred spanning two generations. The founder, daughter and niece underwent surgery for gastric cancer (GC); a son and other two daughters of the founder, presented with chronic dyspepsia. In all subjects, gastric mucosa samples were analysed for...

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PMID: 12855270
DOI: 10.1016/s0959-8049(03)00368-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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