After Helicobacter pylori, genetic susceptibility to gastric carcinoma revisited.

Abstract excerpt

Genetically, it is possible to distinguish two main forms of gastric carcinoma (GC): a hereditary form in which the initiating genetic alteration is inherited and the remaining mutations are acquired somatically; and a sporadic form in which every mutation is of somatic origin and where the environment is thought to play a major role. Although rare, the identification of germline mutations is proving invaluable...

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