Article
Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil1.
Gastroenterology - 1 Jul 2003
Westland Chris, Delaney William, Yang Huiling, Chen Shan-Shan, Marcellin Patrick, Hadziyannis Stephanos, Gish Robert, Fry John, Brosgart Carol, Gibbs Craig, Miller Michael, Xiong Shelly
Abstract excerpt
BACKGROUND & AIMS: Hepatitis B virus (HBV) genotype may influence disease progression and antiviral response. We therefore analyzed the frequency and distribution of genotypes in patients from 2 multinational phase III studies of adefovir dipivoxil. Antiviral efficacy of adefovir dipivoxil 10-mg therapy was examined with respect to HBV genotype, hepatitis B e antigen (HBeAg) serostatus, and race. METHODS: HBV...
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