Article
NFATc1 with AP-3 site binding specificity mediates gene expression of prostate-specific-membrane-antigen.
Journal of molecular biology - 18 Jul 2003
Lee Sang-Jin, Lee KangRyul, Yang Xiumei, Jung Chaeyong, Gardner Thomas, Kim Hong-Sup, Jeng Meei-Huey, Kao Chinghai
Abstract excerpt
Prostate-specific-membrane-antigen (PSMA) is a marker protein expressed primarily in prostate epithelium. Its prostate-specific expression is conferred by PSMA enhancer (PSME), localized within the third intron of PSMA-encoding gene FOLH1. We recently reported that the 5'-end 90 bp of PSME harbored crucial enhancer elements for high PSMA expression. Deletion of this 90 bp sequence, called PSME(del3),...
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