Inhibition of c-<i>src</i>Transcription by Mithramycin:  Structure−Activity Relationships of Biosynthetically Produced Mithramycin Analogues Using the c-<i>src</i>Promoter as Target

Abstract excerpt

The aureolic acid antitumor antibiotic mithramycin (MTM) inhibits both cancer growth and bone resorption by cross-linking GC-rich DNA, thus blocking binding of Sp-family transcription factors to gene regulatory elements. Transcription of c-src, a gene implicated in many human cancers and required for osteoclast-dependent bone resorption, is regulated by the binding of Sp factors to specific elements in its...

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