Article
S100B inhibits myogenic differentiation and myotube formation in a RAGE-independent manner.
Molecular and cellular biology - 1 Jul 2003
Sorci Guglielmo, Riuzzi Francesca, Agneletti Anna Lisa, Marchetti Cristina, Donato Rosario
Abstract excerpt
S100B is a Ca(2+)-modulated protein of the EF-hand type with both intracellular and extracellular roles. S100B, which is most abundant in the brain, has been shown to exert trophic and toxic effects on neurons depending on the concentration attained in the extracellular space. S100B is also found in normal serum, and its serum concentration increases in several nervous and nonnervous pathological conditions,...
Topics
- Animals
- Biomarkers
- Cell Differentiation
- Cells, Cultured
- Creatine Kinase
- Dose-Response Relationship, Drug
- Enzyme Activation
- Mitogen-Activated Protein Kinases
- Muscle Fibers, Skeletal
- Mutation
- Myoblasts, Skeletal
- Myogenin
- Myosin Heavy Chains