Article
Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology.
Blood - 15 Oct 2003
Marafioti Teresa, Jones Margaret, Facchetti Fabio, Diss Tim C, Du Ming-Qing, Isaacson Peter G, Pozzobon Michela, Pileri Stefano A, Strickson Amanda J, Tan Soo-Yong, Watkins Fiona, Mason David Y
Abstract excerpt
We describe large B cells, many of which have a stellate or dendritic morphology, found in the interfollicular T-cell-rich areas of human peripheral lymphoid tissue. These B cells probably require CD40/CD40 ligand signaling for their generation and have a unique phenotype and a post-germinal center pattern of immunoglobulin gene mutation. The only comparable B cell is the "asteroid" cell of the thymic medulla....
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