Article
[Problems raised by the gynaecologic management of women with BRCA 1 & 2 mutations].
Gynecologie, obstetrique & fertilite - 1 Apr 2003
Cabaret A S, Levêque J, Dugast C, Blanchot J, Grall J Y
Abstract excerpt
Breast and ovarian cancer occur more frequently in young women with BRCA 1 &2 mutations (respective cumulative risks from 37 to 85% and 10 to 20%), and raise specific gynaecologic problems as prophylactic surgery and hormonal treatments. Two medical files from 2 sisters with BRCA 1 mutation (exon 11) are presented and the authors discuss the therapeutic options chosen. BRCA 1 & 2 tumour suppressor genes seem to...
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