Article
[Recommendations for the management of women with an increased genetic risk of gynaecological cancer].
Nederlands tijdschrift voor geneeskunde - 14 Dec 2002
Verheijen R H M, Boonstra H, Menko F H, de Graaff J, Vasen H F A, Kenter G G
Abstract excerpt
About 5% of all ovarian-cancer cases are caused by a genetic predisposition, in particular as a component of the autosomal dominant hereditary breast-ovarian-cancer syndrome. This syndrome is usually due to germline mutations in the BRCA1- or BRCA2-gene. Ovarian and endometrial cancer also occur in families with hereditary non-polyposis colorectal cancer (HNPCC). This syndrome is caused by germline mutations in...
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