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Article

Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin.

Anticancer research - 1 Jan 2000

Peters Ulrike, Preisler-Adams S, Lanvers-Kaminsky Claudia, Jürgens Heribert, Lamprecht-Dinnesen Antoinette

Abstract excerpt

BACKGROUND: Since mutations in the mitochondrial genome are associated with hearing loss, we analyzed whether sequence variations of mtDNA are associated with individual sensitivity to cisplatin-induced ototoxicity. MATERIALS AND METHODS: The mtDNA of 20 patients with and 19 patients without hearing impairment under therapeutic doses of cisplatin was sequenced for mutations and characterized for haplotype by...

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PMID: 12820379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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