Article
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma.
Oncogene - 19 Jun 2003
Pedersen Tanja Xenia, Leethanakul Chidchanop, Patel Vyomesh, Mitola David, Lund Leif Røge, Danø Keld, Johnsen Morten, Gutkind J Silvio, Bugge Thomas Henrik
Abstract excerpt
Keratinocytes undergo a dramatic phenotypic conversion during reepithelialization of skin wounds to become hyperproliferative, migratory, and invasive. This transient healing response phenotypically resembles malignant transformation of keratinocytes during squamous cell carcinoma progression. Here we present the first analysis of global changes in keratinocyte gene expression during skin wound healing in vivo,...
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