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Article

The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway.

Human molecular genetics - 1 Jul 2003

Cobbold Christian, Coventry Julie, Ponnambalam Sreenivasan, Monaco Anthony P

Abstract excerpt

The Menkes disease gene encodes a P-type transmembrane ATPase (ATP7A) that translocates cytosolic copper ions across intracellular membranes of compartments along the secretory pathway. ATP7A moves from the trans-Golgi network (TGN) to the cell surface in response to exogenously added copper ions...

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Source

Identifiers

PMID: 12812980
DOI: 10.1093/hmg/ddg166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12812980-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway.PMID 12812980Read ↗

Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (ATP7A; MNK). Endocytosis of the Menkes protein.Semantic proximity Read ↗

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.Semantic proximity Read ↗

Menkes disease.Semantic proximity Read ↗

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.Semantic proximity Read ↗

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.Semantic proximity Read ↗

Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.Semantic proximity Read ↗

Direct interactions of adaptor protein complexes 1 and 2 with the copper transporter ATP7A mediate its anterograde and retrograde trafficking.Semantic proximity Read ↗

Characterization of the Menkes protein copper-binding domains and their role in copper-induced protein relocalization.Semantic proximity Read ↗

Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.Semantic proximity Read ↗

Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease.Semantic proximity Read ↗

Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7BSemantic proximity Read ↗

Autonomous requirements of the Menkes disease protein in the nervous system.Semantic proximity Read ↗

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