Article
Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A.
Molecular human reproduction - 1 Jul 2003
De Vos A, Sermon K, De Rijcke M, Goossens V, Henderix P, Van Ranst N, Platteau P, Lissens W, Devroey P, Van Steirteghem A, Liebaers I
Abstract excerpt
Charcot-Marie-Tooth (CMT) disease is the 'common' name for a range of hereditary peripheral neuropathies. CMT1 is the most common form and is transmitted in an autosomal dominant manner. CMT1A maps to chromosome 17p11.2 and is caused, in the majority of cases, by a 1.5 Mb DNA duplication, that includes the peripheral myelin protein 22 (PMP) gene. This paper reports on preimplantation genetic diagnosis (PGD) for...
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