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Article

Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.

Nucleic acids research - 15 Jun 2003

Campillos Mónica, Lamas José Ramón, García Miguel Angel, Bullido María Jesús, Valdivieso Fernando, Vázquez Jesús

Abstract excerpt

The polymorphic -219T/G variant in the APOE promoter has been associated with variations in basal transcriptional activity as well as with the risk of developing Alzheimer's disease, myocardial infarction and early-onset coronary heart disease. The molecular mechanisms underlying these effects ar...

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Source

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Identifiers

PMID: 12799433
DOI: 10.1093/nar/gkg435
PMCID: PMC162339

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12799433-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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