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Article

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

1 Jun 2003

Abstract excerpt

OBJECTIVE: To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis. METHODS: Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored. RESULTS: Systemic...

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PMID: 12794839
DOI: 10.1002/art.11035

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