Article
Ten families of variant genes encoded in subtelomeric regions of multiple chromosomes of Plasmodium chabaudi, a malaria species that undergoes antigenic variation in the laboratory mouse.
Molecular microbiology - 1 Jun 2003
Fischer Katja, Chavchich Marina, Huestis Robert, Wilson Danny W, Kemp David J, Saul Allan
Abstract excerpt
The chromosome ends of human malaria parasites harbour many genes encoding proteins that are exported to the surface of infected red cells, often being involved in host-parasite interactions and immune evasion. Unlike other murine malaria parasites Plasmodium chabaudi undergoes antigenic variation during passage in the laboratory mouse and hence is a model suitable for investigation of switching mechanisms....
Topics
- Animals
- Animals, Laboratory
- Antigenic Variation
- Chromosomes
- Chromosomes, Artificial, Yeast
- Cloning, Molecular
- Electrophoresis, Gel, Pulsed-Field
- Gene Library
- Genes, Protozoan
- Genetic Variation
- Mice
- Molecular Sequence Data