Article
Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a Type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18.
The Journal of investigative dermatology - 1 Jun 2003
Lebre M Cristina, Antons Jeanine C, Kalinski Pawel, Schuitemaker Joost H N, van Capel Toni M M, Kapsenberg Martien L, De Jong Esther C
Abstract excerpt
Dendritic cells play a key role in establishing the class of immune response against invading pathogens. Upon engagement with double-stranded RNA, a major bioactive constituent of many virus types, immature dendritic cells develop into type 1 immunostimulatory dendritic cells that promote Th1 responses. Immature dendritic cells reside in the epithelia and are in close contact with keratinocytes. We studied to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.