Article
Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia.
Psychiatric genetics - 1 Jun 2003
Georgieva Lyudmila, Nikolov Ivan, Poriazova Nadezhda, Jones Gaynor, Toncheva Draga, Kirov George, Owen Michael J
Abstract excerpt
OBJECTIVES: Cadherins play a critical role in morphogenesis and maintenance of neuronal connections in the adult brain. We examined the gene encoding a member of the non-classic seven-pass transmembrane cadherins, CELSR1 for association with schizophrenia. It maps to chromosome 22q13.31, a region in which evidence for linkage to schizophrenia has been reported. The gene has an unusually large first exon of 3544...
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