Article
Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic.
Biochemistry - 3 Jun 2003
Dioumaev Andrei K, Wang Jennifer M, Bálint Zoltán, Váró György, Lanyi Janos K
Abstract excerpt
At pH >7, proteorhodopsin functions as an outward-directed proton pump in cell membranes, and Asp-97 and Glu-108, the homologues of the Asp-85 and Asp-96 in bacteriorhodopsin, are the proton acceptor and donor to the retinal Schiff base, respectively. It was reported, however [Friedrich, T. et al. (2002) J. Mol. Biol., 321, 821-838], that proteorhodopsin transports protons also at pH <7 where Asp-97 is protonated...
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