Article
Functional activity of serotoninergic and melatoninergic systems expressed in the skin.
Journal of cellular physiology - 1 Jul 2003
Slominski Andrzej, Pisarchik Alexander, Zbytek Blazej, Tobin Desmond J, Kauser Söbia, Wortsman Jacobo
Abstract excerpt
We tested the expression of genes coding receptors of a cutaneous serotoninergic/melatoninergic system in whole human skin and in normal and pathologic cultured skin cells. Evaluation of serotonin (5HT), melatonin (MT), and melatonin-related receptors (MRR) showed expression of the isoforms 5HT2B, 5HT7, and MT1 genes in almost all the tested samples. Expression of other isoforms was less prevalent; 5HT2C, MRR,...
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